UNITY Biotechnology, Inc. Announces First Patient Treated in UBX0101 Phase 1 Trial for Osteoarthritis of the Knee
UNITY Biotechnology, Inc. Announces First Patient Treated in UBX0101 Phase 1 Trial for Osteoarthritis of the Knee
June 25, 2018
“For many people, we believe that osteoarthritis is the main reason why it hurts to get old,” said
“This is an important milestone for UNITY,” said
About the UBX0101 Phase 1 Clinical Trial
The Phase 1 clinical trial of UBX0101 is a randomized, double-blind, placebo-controlled, single ascending dose study that will evaluate safety, tolerability and pharmacokinetics of a single intra-articular injection of UBX0101 in patients diagnosed with moderate to severe osteoarthritis of the knee. Patients will be randomly assigned to receive UBX0101 or placebo in 3:1 randomization by dose level cohort. Additional information about the trial can be found on www.clinicaltrials.gov.
About Cellular Senescence and Senolytic Medicines
Cellular senescence is a natural biological state in which a cell permanently halts division. Senescent cells accumulate with age and secrete as many as 100 different biologically active proteins, including pro-inflammatory factors, proteases, pro-fibrotic factors and growth factors that disturb the tissue microenvironment. This collection of secreted proteins is referred to as the Senescence Associated Secretory Phenotype, or SASP. In addition to its effects on tissue function, the SASP contains factors that induce senescence in neighboring cells, setting off a cascade of events that culminates in the formation of the functionally aged and/or diseased tissue that appears to underlie a variety of age-associated diseases. UNITY believes that the elimination of senescent cells will remove SASP factors—addressing a root cause of diseases of aging. Senolytic medicines, or treatments designed to selectively remove senescent cells, target the SASP at its source, and may have a more durable impact on disease than current therapies.
About
Forward-Looking Statements
This press release contains forward-looking statements, including but not limited to statements related to our potential to selectively eliminate senescent cells and thereby treat patients with osteoarthritis. Such forward-looking statements involve substantial risks and uncertainties that could cause UNITY’s research and clinical development programs, future results, performance or achievements to differ significantly from those expressed or implied by the forward-looking statements. Such risks and uncertainties include, among others, the uncertainties inherent in the drug development process, including UNITY’s early stage of development and its understanding of senescence biology, the clinical trial enrollment process, the regulatory approval processes, the timing of regulatory filings, the challenges associated with manufacturing drug products, UNITY’s ability to successfully protect and defend its intellectual property, and other matters that could affect the sufficiency of existing cash to fund operations and the availability or commercial potential of UNITY’s product candidates. UNITY undertakes no obligation to update or revise any forward-looking statements. For a further description of the risks and uncertainties that could cause actual results to differ from those expressed in these forward-looking statements, as well as risks relating to the business of the Company in general, see UNITY’s recently filed Registration Statement on Form S-1 and any subsequent current and periodic reports filed with the
InvestorsEndurance Advisors Elizabeth Broder ebroder@enduranceadvisors.com MediaCanale Communications Jason Spark 1-619-849-6005 jason@canalecomm.com
Source: Unity Biotechnology, Inc.